A complex system that works is invariably found to have evolved from a simple system that worked.A complex system designed from scratch never works and cannot be patched up to make it work.
So you didn't describe very well the issue from the beginning.
As I understood, in CubeMx, you set LSE clock to 32.768Hz. When you enable I2C4, an issue appears on LSE clock. Is that what you are facing as a problem? please be more specific and clear with your descriptions, what is the H7 part number? is that possible to share the ioc file?
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