Hi Francesco,
The ST25R3911B-DISCO cannot be debugged without external debugger. It does not have an on-board ST-Link. You will need to attach an external debugger to the Cortex-M 9-pin debug interface.
Firmware update on the ST25R3911B-DISCO works through the USB DFU bootloader inside STM32L476. If that is not working then you may be hit by new driver coming with STM32CubeProgrammer. You can resolve by:
1. Go to device manager, search “Universal Serial Bus devices -> STM32 Bootloader�? (winusb.sys in the driver details)
2. Uninstall with “Delete the driver software for this device�? checked (!)
3. Reset the board, keeping USB DFU mode: e.g. press boot button while resetting
4. Go to device manager, search “Other devices -> STM32 BOOTLOADER�? (no driver installed)
5. “Update driver software�?, select e.g. C:\PROGRAM FILES (X86)\STMICROELECTRONICS\ST25R3916_DISCOVERY_GUI\DRIVER\DFUSE
6. Now there should be an “Universal Serial Bus controllers -> STM Device in DFU mode�? (STTub30.sys in the driver details) in the device manager and firmware update should work.
Regards, Ulysses