That's a good question to ask. Disabling this service means that the HSI clock will derive. If you have devices such as UARTs that are clocked with the HSI and this clock is not trimmed, you risk facing loss of data (Could be a derivation close to +/- 10%).
As we'll only support deep low-power modes (no wakeup from UART) with the RT flavor, I suggest to clock the peripherals with HSE (if you have a custom board, that's guessing you have one), that do not require calibration. The use of HSI is relevant, for example, when supporting light low-power modes when the CPU is in IDLE and you want to wakeup fast when typing a character in the console.
Extract from stm32mp257c datasheet :
If better tolerance is needed (for example for UART kernel clock usage), the HSI could be trimmed during run time by measuring its frequency with a better reference like HSE crystal. The HSI trimming must be done regularly or whenever there is significant variation on supply voltage or temperature.
I will enter a ticket internally so that we provide a RT device tree that do not clock UARTs with HSI.
Best regards,
Gatien